CTCF is widely recognized for its essential role in mediating chromatin loops to regulate gene expression, particularly by modulating enhancer-promoter (EP) interactions. However, acute depletion of ...
Biology is never as straightforward as we learned in high school. Take sex-linked chromosomes as an example: we’re taught that biological males get XY chromosomes while biological females get two ...
Two protein complexes carry the major responsibility for the spatial organization of chromosomes in our cell nuclei, and DNA tension plays a surprising role in this. Nanoscientist Cees Dekker and his ...
In a recent study published in the journal Nucleic Acids Research, researchers investigate whether machine learning can identify pan-cancer mutational hotspots at persistent CCCTC-binding factor ...
It has been known for more than a century that the long DNA strands in cell nuclei are neatly folded into the characteristic shape of chromosomes, resembling bottlebrushes , in preparation for cell ...
Scientists discovered another key to how DNA forms loops and wraps inside the cell nucleus—a precise method of "packing" that may affect gene expression. The journal Science published the research by ...
Ganji M et al., and Fudenberg G et al., postulated that the SMC family of ATPases, such as condensin and cohesion, extrude DNA into large loops. Energy from ATP hydrolysis helps the SMC proteins to ...
Two protein complexes carry the major responsibility for the spatial organization of chromosomes in our cell nuclei. DNA tension plays a surprising role in this. Nanoscientists now publish how they ...
New research shows that a process known as hemimethylation plays a role in looping DNA in a specific way. Researchers also demonstrated that hemimethylation is maintained deliberately -- not through ...
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